Endocrine Abstracts

Introduction: Survivin is a multifunctional protein and acts as an inhibitor of apoptosis. Its expression occurs in nearly all human cancers. In some tumors survivin expression correlates with the malignant behavior and diminished response to cytotoxic therapy. Data concerning survivin expression in invasive pituitary gland adenomas are contradictory.Patients and methods: Survivin expression was assessed in 38 invasive pituitary gland adenomas (31 non-fu...

Introduction: Thyroid cancer incidence has increased significantly during the past decades and is the most common type of endocrine malignancy. Suitable criteria for detecting malignant thyroid tumors are still missing. Therefore, the discovery of molecular markers linked to thyroid carcinogenesis will be helpful in the diagnosis of malignant tumors and managing their appropriate treatment.Aim: The objective of the study was to evaluate survivin expressi...

Irisin is a recently reported, widely discussed new adipo-myokin secreted mainly by muscle tissue. It is a cleaved and secreted part of fibronectin type III domain containing 5, encoded by the FNDC5 gene. Some of the previously published studies claim that alterations of irisin levels in patients affected by thyroid diseases may be connected mainly with accompanying myopathy. However, to date it has not been evaluated, whether the changes in expression of FNDC5</e...

Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves’ orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves’ disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent th...